The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Biomarkers, 2010Oxidized DJ-1 as a Biomarker for Parkinson's Disease
Objective/Rationale:
Mutations in the DJ-1 gene are associated with an early-onset familial form of PD and DJ-1 protein has been shown to be decreased in the CSF of sporadic PD compared to controls. ... -
Target Validation, 2010Pharmacological PHD Inhibition as a Potential PD Neuroprotectant Therapy
Objective/Rationale:
A growing body of evidence suggests that iron dysregulation may contribute to neurodegeneration associated with Parkinson’s disease (PD). Recent work from our laboratory suggests... -
Rapid Response Innovation Awards, 2010Protecting Innervation: Nmnat1 Gene Therapy for Parkinson's Disease
Objective/Rationale:
Axonal degeneration is a major pathological hallmark of Parkinson’s disease (PD). Evidence gathered in PD patients indicates that pathology in axons occurs prior to and... -
Rapid Response Innovation Awards, 2010Genetic-epidemiological Confirmation of Top Hits of GWAS of Parkinson Disease: A Large Multi-center Collaborative Study
Objective/Rationale:
A critical question which is still unresolved in the post GWAS (genome-wide association study) era focuses on the role of non genetic factors conferring either a risk or... -
Rapid Response Innovation Awards, 2010Development of a Progressive Familial Pre-clinical Model of Parkinson's Disease
Objective/Rationale:
Although a number of genes have been identified that lead to Parkinson’s disease in humans, the scientific community has yet to be able to recapitulate this in pre-clinical... -
Critical Challenges in PD: Alpha-synuclein Neuroimaging, 2010Development and Screening of Contrast Agents for In-vivo Imaging of Parkinson's Disease
Promising Outcomes of Original Grant:
The goals of the original grant were to screen a library of compounds to identify leads for non-invasive imaging of PD pathology. We used cell culture models of...
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Our funding programs support basic, translational and clinical research from academia and industry.