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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • MJFF Research Grant, 2011
    Development of Highly Sensitive and Specific Antibodies Against Oxidized DJ-1 as a Biomarker for Parkinson's Disease

    Objective/Rationale:
    Mutations in the DJ-1 gene are associated with an early-onset familial form of PD and DJ-1 protein has been shown to be lower in the CSF of sporadic PD compared to controls. DJ-1...

  • Defining Cognitive Phenotypes of Parkinson’s Disease, 2011
    Neurochemical Correlates of Cognitive Phenotypes in PD

    Objective/Rationale:
    Parkinson’s disease causes neurodegeneration in multiple subcortical nuclei, including substantia nigra, locus coeruleus, dorsal raphe nucleus, and nucleus basalis. Each of these...

  • LRRK2 Cohort Consortium, 2011
    Autonomic Profiles of LRRK2 Mutation Carriers with Parkinson’s Disease and Non-manifesting, First-degree Relatives

    Objective/Rationale:
    Autonomic disturbances are common symptoms of Parkinson’s disease (PD). We propose to analyze data on autonomic function collected from PD patients and relatives of PD patients...

  • Research Grant, 2011
    Pre-clinical Development of Encapsulated Cell Biodelivery of GDNF for Parkinson's Disease

    Objective/Rationale:
    Glial cell line-derived neurotrophic factor (GDNF) is a protein that can aid in survival of the dopamine cells that die in Parkinson’s disease (PD). Treatment with GDNF in PD has...

  • Rapid Response Innovation Awards, 2010
    Generation of a Novel Recombinant Protein Activator of GPR88

    Objective/Rationale
    Dopamine replacement therapy activates neurons in a particular region of the brain, the striatum, leading to an improvement in disease symptoms. This action occurs through a...

  • Rapid Response Innovation Awards, 2010
    Circulating microRNAs as Biomarkers for Early Detection of Parkinson's Disease

    Objective/Rationale:
    MicroRNAs (miRNAs) are small, conserved RNAs that interact with target sequences on messenger RNAs. MiRNAs have been proven to regulate the expression of many genes and play...

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