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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2008
    Role of Peripheral Enteric Inflammation in Synuclein Pathology in a Murine Model of Parkinson's Disease

    Objective/Rationale:
    Gastrointestinal dysfunction has long been noted as an early feature of Parkinson’s disease, and “in many cases demands stimulating medicines of very considerable power” (James...

  • Rapid Response Innovation Awards, 2008
    Effects of noradrenergic or serotoninergic system lesions combined with NS lesions on rodent models of 'non-motor'-like symptoms

    Objective/Rationale:
    Parkinson’s disease is widely attributed to neuropathy of dopaminergic neurones in the nigrostriatal (NS) pathway. Degeneration of noradrenergic and serotonergic neurones in the...

  • Cognitive Deficits and Mood Disorders in Parkinson's Disease, 2008
    Neuroimaging Markers Predict Cognitive Decline in PD

    Objective/Rationale:
    Isolated cognitive impairments are common in PD; they increase in number and severity with advancing age and motor disability but their relation to the risk of developing dementia...

  • Cognitive Deficits and Mood Disorders in Parkinson's Disease, 2008
    Validation of the Dopamine-depleted CHT Hemizygous Pre-Clinical Model as an Animal Model of Parkinson's Disease with Dementia

    Objective/Rationale:
    Parkinson’s disease is traditionally thought of as a motor disorder. However, in addition to problems with movements, patients frequently develop cognitive problems leading to...

  • Cognitive Deficits and Mood Disorders in Parkinson's Disease, 2008
    Validating the Montreal Cognitive Assessment for the Diagnosis of Mild Cognitive Impairment in Parkinson's Disease

    Objective/Rationale:
    Dementia affects up to 80 percent of Parkinson’s disease patients, and the prevalence of other dementias including Alzheimer’s disease is high in this age group. A need exists for...

  • Cognitive Deficits and Mood Disorders in Parkinson's Disease, 2008
    A Rodent Model of Pathological Gambling Associated with Medicated Parkinsonian Patients

    Objective/Rationale:
    The increase in impulsive and risky behaviors, like gambling, hyper-sexuality, and compulsive shopping are emotionally and financially devastating, and impose a significant burden...

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