The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Novel Approaches to Drug Discovery for Parkinson's Disease, 2007Targeting the PTEN/mTOR/Autophagy Pathway
Objective/Rationale:
A major hurdle in the development of drugs for Parkinson's disease (PD) is the lack of accurate animal models for the disease. We describe new animal models that harbor defects... -
Rapid Response Innovation Awards, 2007Development of a Cellular System to Screen for Small Molecules that Upregulate the hVMAT2 Promoter Activity
Objective/Rationale:
We will develop an essential cellular system as a platform for future high throughput screen (HTS) for novel small molecules that increase levels of the human vesicular monoamine... -
Rapid Response Innovation Awards, 2007Development and Initial Characterization of an Enzyme-linked Immunosorbent Assay for the Candidate PD Risk Marker ST13
Objective/Rationale:
Clinical signs of Parkinson’s disease develop only after the death of around 70 percent of vulnerable dopaminergic neurons. Laboratory tests for PD are not currently available... -
Rapid Response Innovation Awards, 2007Methylphenidate for the Treatment of Gait Impairment in Parkinson's Disease
Objective/Rationale:
The objective of this study is to explore the effects of methylphenidate on the gait of patients with Parkinson’s disease who are experiencing shuffling and freezing... -
Rapid Response Innovation Awards, 2007Understanding the Molecular and Functional Changes of CB1/D2/A2A Receptor Complexes in the Hemi-parkinsonian Pre-clinical Model
Objective/Rationale:
Future therapies in Parkinson’s disease (PD) may derive from the existence of intramembrane heteromeric receptor complexes containing the dopamine D2 receptor. The ability of... -
Rapid Response Innovation Awards, 2007A Novel Strategy for the Selection and Transplantation of Dopamine-Specified Human Embryonic Stem Cells
In parkinson’ disease (PD), neurodegeneration is largely confined to one discrete group of nerve cells that produce the chemical dopamine (DA). Since the death of most DA neurons almost always...
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