The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2019Biologically Meaningful Modulation of Alpha-synuclein Expression via Clenbuterol
Promising Outcomes of Original Grant:
The drug clenbuterol, a beta-2 adrenoreceptor agonist, has been shown to decrease alpha-synuclein expression and to be neuroprotective in some models. Our results... -
Biomarkers of Protein Handling/Autophagy, Exosomes and Lipid, 2019Measuring Lipids in iPSC-derived Dopamine Neurons to Identify Parkinson’s Biomarkers
Study Rationale:
Changes in lipid metabolism have been strongly associated with Parkinson’s disease (PD). Lipids have the potential to be important biomarkers for PD, but the lack of appropriate tools... -
Improved Biomarkers and Clinical Outcome Measures, 2019GBA Sequencing and Detection of Mutations, Deletions, Insertions and Recombinations with the GBA Pseudo Gene
Study Rationale:
Mutations in the GBA gene are the most common genetic cause of Parkinson’s disease. This gene has a nearby pseudogene, which is a genetic material that is very similar to the original... -
Alpha-synculein Biology and Therapies, 2019Chaperones of Alpha-synuclein for Membrane Fusion Involved in Synaptic Transmission
Study Rationale:
Abnormal accumulation of the protein alpha-synuclein is a pathological hallmark of Parkinson’s disease (PD). We and others have evidence that aggregated alpha-synuclein could harm... -
Non-pharmacological Interventions for Gait and Balance, 2019Project Holocue: Smart Wearable Assistive Cueing Device for Reducing Freezing of Gait
Study Rationale:
Cues, such as stripes on the ground, may help alleviate and sometimes even prevent freezing of gait in people with Parkinson's disease. However, different people prefer different... -
Non-pharmacological Interventions for Gait and Balance, 2019Vibrating Socks: A Novel Cueing Intervention to Reduce Freezing of Gait in Parkinson's Disease
Study Rationale:
Freezing of gait is a common and disabling symptom in Parkinson's disease. With freezing of gait, patients have the feeling that their feet are suddenly glued to the floor when they...
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Our funding programs support basic, translational and clinical research from academia and industry.