The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2, 2011The Role of LRRK2 in Regulating a Calcium-Dependent Pathway Involving Lysosomal Stores and NAADP
Objective/Rationale:
Our preliminary evidence indicates that LRRK2 may regulate acidic calcium stores, with downstream effects on autophagy as well as a variety of other calcium dependent cellular... -
Target Validation, 2011Tau Oligomers as a Potential Target for Treatment of Parkinson's Disease
Objective/Rationale:
Tau pathology is a prominent feature of synucleinopathies, such as Parkinson disease (PD) and dementia with Lewy Bodies (DLB). An emerging view in neurodegeneration is that... -
MJFF Research Grant, 2011Generation of Monoclonal and Polyclonal Antibodies against LRRK1
Objective/Rationale:
There is great excitement that drugs targeting an enzyme called LRRK2 may have utility in the treatment of Parkinson’s disease. Some companies are attempting to develop LRRK2... -
MJFF Research Grant, 2011Generation of Monoclonal and Polyclonal Antibodies Against Aggregated Forms of Alpha-Synuclein
Objective/Rationale:
The aggregation of alpha-synuclein plays a pivotal role in the development of Parkinson’s disease. This subproject focuses on supporting the MJFF initiative of generating... -
MJFF Research Grant, 2011Implementation of PD GWAS meta-analysis results on the PDGene database
Objective/Rationale:
The goal of this proposal is to analyze all available Parkinson’s disease (PD) genomewide association study (GWAS) datasets so that we can identify gene variants associated with... -
MJFF Research Grant, 2011Axonopathy induced by overexpression of human -synuclein in the rat nigrostriatal dopamine system
Objective/Rationale:
Observations made in brains from patients with Parkinson’s disease indicate that the disease may start at the level of the axons and that loss of the affected neurons occur later...
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Our funding programs support basic, translational and clinical research from academia and industry.