The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2019Identification of Novel Compounds that Improve Mitochondrial Quality Control
Study Rationale:
Dysfunction of mitochondria, the powerhouses of the cell, has been linked to degeneration in nerve cells in Parkinson’s disease. When mitochondria can’t function properly, cellular... -
Improved Biomarkers and Clinical Outcome Measures, 2019Applying Artificial Intelligence for Early Identification of Parkinson’s Disease
Study Rationale:
The nervous system regulates heart rate in response to situations such as stress and emergencies. Dysfunction of part of the nervous system controlling the heart can cause changes in... -
Research Grant, 2019Enhancing the Clinical Utility of Data-Driven Parkinson’s Subtypes with Knowledge Distillation and Visualization
Study Rationale:
Data-driven analytics, such as machine learning methods, have been applied to discover comprehensive Parkinson’s disease (PD) subtypes from observational patient data. However, many... -
Research Grant, 2019Measurement of BMP and NAG Activity in CSF Samples
Study Rationale:
Mutations in the LRRK2 gene are a common cause of dominantly inherited Parkinson’s disease (PD). Previous studies showed that urine levels of a lipid [di-22:6-bis(monoacylglycerol... -
Research Grant, 2019Mechanistic Characterization of the PINK1-amplifying Compound MTK-458
Study Rationale:
Loss-of-function mutations in components of the PINK1/PRKN pathway lead to early onset Parkinson’s disease. Previous work by our company has shown that our compounds can amplify the... -
Research Grant, 2019Supplement: Investigation of PINK1-dependent Phosphorylation of Rab GTPases
Promising Outcomes of Original Grant:
We were trying to understand how the PINK1 gene targets a set of proteins known as Rab GTPases through protein modification known as phosphorylation. The...
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Our funding programs support basic, translational and clinical research from academia and industry.