The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Advancement Program, 2020The Role of Cannabinoid Receptor 2 in Inflammatory Responses Triggered by Alpha-synuclein
Study Rationale:
There is growing interest in the anti-inflammatory properties of cannabis-related compounds as a potential therapy for Parkinson’s disease (PD). Cannabis, or marijuana, acts on... -
Therapeutic Pipeline Program, 2020Phase II Trial of Bone Marrow-Derived Mesenchymal Stem Cells as a Disease-Modifying Therapy for Parkinson’s Disease
Study Rationale:
Chronic brain inflammation plays a critical role in the development and progression of Parkinson’s disease. This inflammation damages the brain, disrupts the blood-brain barrier, and... -
Improved Biomarkers and Clinical Outcome Measures, 2020Predicting Conversion to Parkinson’s Disease Based on Proteomic Biomarkers in a Large Prospective Cohort
Study Rationale:
The ultimate aim in Parkinson’s disease research is to identify individuals at risk for developing Parkinson’s prior to disease onset. To reach this goal, a set of informative markers... -
Research Grant, 2020Targeting TNFR2 in a Model of Parkinson’s Disease
Study Rationale:
In previous research, we demonstrated that the protein tumor necrosis factor receptor 2 (TNFR2) plays an essential role in reducing inflammation in the peripheral and central nervous... -
Therapeutic Pipeline Program, 2020Development of Novel Parkin Activators
Study Rationale:
In Parkinson’s disease, brain cells die when their mitochondria (structures that create energy for the cells) are damaged and cannot be removed efficiently. An enzyme called parkin... -
Research Grant, 2020Identification of Therapeutic Circuits to Address Anxiety and Depression Symptoms in Parkinson’s Disease
Study Rationale: Parkinson’s disease patients often experience depression and anxiety. Addressing these non-motor symptoms has not been the focus of Parkinson’s disease research though psychiatric...
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Our funding programs support basic, translational and clinical research from academia and industry.