The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2018Improving Existing LRRK2 Tests with Novel Reagents
Promising Outcomes of Original Grant:
The goal of our original study was to determine the best conditions for collecting and processing blood cells intended for testing the function of LRRK2, a protein... -
Research Grant, 2018Studying Lipids in the Blood as Indicators of Pre-clinical and Early Parkinson’s Disease
Study Rationale:
There is a need for biomarkers -- disease measures -- that indicate and can help diagnose early-stage Parkinson’s disease (PD). Identification of PD during this stage, in the absence... -
Research Grant, 2018Creating a Fluorescent Tag for Protein GCase in Blood Cells
Study Rationale:
About 10 percent of people with Parkinson disease (PD) carry changes in the GBA gene that cause malfunction of a protein called glucocerebrosidase (GCase). People with Parkinson’s... -
Research Grant, 2018A Role of Protein Parkin in Innate Immunity
Study Rationale:
There is growing evidence that some genes associated with Parkinson's disease (PD) also play a role in immunity. Changes in PRKN -- a gene that directs the production of protein... -
LRRK2 Therapeutic and Safety Initiative, 2018Studying the Effect of p62 on the Toxicity of LRRK2 in the Brain
Study Rationale:
Mutations (changes) in the LRRK2 gene are a leading genetic cause of Parkinson's disease (PD). They cause dysfunction in the LRRK2 protein, making it toxic to the brain. Protein LRRK2... -
Research Grant, 2018The Role of FcgRIIb in Alpha-synuclein Toxicity and Spread
Study Rationale:
People with Parkinson's disease (PD) have clumps of protein alpha-synuclein in the brain. As PD progresses, these clumps spread through the brain, damaging nerve cells (neurons) that...
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Our funding programs support basic, translational and clinical research from academia and industry.