The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 in the Immune System, 2012Parkinson's and Inflammatory Bowel Diseases: Interaction in LRRK2 Transgenic Pre-clinical models
Objective/Rationale:
Mutations in LRRK2 are the most common cause of genetic PD. LRRK2 has also been recently linked to inflammatory bowel diseases (IBD), such as Crohn’s and ulcerative... -
Rapid Response Innovation Awards, 2012Effect of Tyrosine on Orthostatic Hypotension in Parkinson’s Disease
Objective/Rationale:
Orthostatic hypotension is a sudden drop in blood pressure (BP) when an individual changes position. Individuals with Parkinson’s disease (PD) commonly suffer from orthostatic... -
Rapid Response Innovation Awards, 2012Investigation of the Mechanisms Involved in Alpha-synuclein Secretion In Vivo
Objective/Rationale:
Extracellular alpha-synuclein appears to be central in the pathogenesis, and perhaps progression of PD. The mechanism(s) underling alpha-synuclein secretion are... -
MJFF Research Grant, 2012Consortium to Identify LRRK2 Modifiers of Age of Onset
Objective/Rationale:
We propose to design and complete a collaborative study that will bring together data and samples from subjects with LRRK2 mutations with the express goal of... -
MJFF Research Grant, 2012Targeting the Unfolded Protein Response (UPR) Transcription Factor XBP1 to Alleviate Neurodegeneration Triggered by Alpha-synuclein
Objective/Rationale:
Our general aim is to investigate the role of a specific component of a cellular stress response, known as the Unfolded Protein Response, in the development of Parkinson's disease... -
MJFF Research Grant, 2012Mechanisms of Cellular Regulation and Post-translational Modification of LRRK2
Promising Outcomes of Original Grant:
We have identified methods to increase or decrease the ratio of cytosolic LRRK2 compared to membrane-localized LRRK2 as well as methods to increase or decrease the...
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Our funding programs support basic, translational and clinical research from academia and industry.