The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2010Generation of Phosphospecific LRRK2 Antibodies
Objective/Rationale:
LRRK2 (Leucine-Rich Repeat Kinase 2) is a protein thought to be involved in regulating signaling pathways in cells. Mutations in the gene for LRRK2 are associated with some... -
MJFF Research Grant, 2010Generation of PINK1 Antibodies
Objective/Rationale:
PINK1 (PTEN-Induced Kinase 1) is a protein involved in regulating signaling pathways in the energy “powerhouse” of cells, known as mitochondria. Mutations in the gene for PINK1 are... -
Target Validation, 2010Gremlin-1, a Putative VTA-derived Neuroprotective Factor in Parkinson's Disease
Objective/Rationale:
We recently showed that certain brain neurons which are normally protected from Parkinson’s disease (PD) contain high levels of the developmental factor Gremlin-1. The goal of this... -
Target Validation, 2010Treating Early Cognitive Impairments and Associated Movement Control Deficits by Stimulating alpha4beta2* nAChRs
Objective/Rationale:
Cholinergic systems decline early in PD and are hypothesized to contribute to cognitive impairments as well as to impairments in performing complex movements and postural... -
Rapid Response Innovation Awards, 2010Down-regulation of GDNF Signaling in the Alpha-synuclein Model of PD: Implications for the Use of GDNF in Neuroprotective Therapy
Objective/Rationale:
GDNF is currently the most effective, and best studied, survival factor acting on dopamine neurons (the neurons that die in Parkinson´s disease, PD). Infusion of GDNF into the... -
Rapid Response Innovation Awards, 2010Identification of Small-molecule Stabilizers of DJ-1: Biophysical and Cellular Validation
Objective/Rationale:
The goal of our project is to develop an approach to treat PD by stabilizing wild-type dimeric DJ-1 with a small molecule. We hypothesize that this approach will lead to an...
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Our funding programs support basic, translational and clinical research from academia and industry.