The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Understanding LRRK2 Biology, 2009LRRK2 in Neuronal Architecture
Objective/Rationale:
Past observations in LRRK2 pre-clinical models have lead us to develop a unified hypothesis for LRRK2’s role in signaling/scaffolding and neuronal membrane dynamics. By utilizing... -
Understanding LRRK2 Biology, 2009Investigating signaling pathway dysfunction linked to LRRK2
Objective/Rationale:
Mutations in the gene LRRK2 are responsible for tens of thousands of cases of Parkinson’s disease, and are the most common genetic cause of this disease. At present we don’t... -
Understanding LRRK2 Biology, 2009Biochemical Characterization of Full Length Human Recombinant LRRK1 and LRRK2
Objective/Rationale:
Mutations in one gene, LRRK2, are a common cause of Parkinson’s disease. However, the protein product of this gene is large and complex and, to date, no one has been able to make... -
Understanding LRRK2 Biology, 2009LRRK2 Mediated Pathogenic Pathways in Dopaminergic Axonal Degeneration and Synaptic Transmission
Objective/Rationale:
Mutations in the LRRK2 gene occur with high frequency in familial and sporadic Parkinson disease. We have established a R1441G-LRRK2 transgenic pre-clinical model that... -
Understanding LRRK2 Biology, 2009Identification of LRRK2 Substrates in Pre-clinical Models of Parkinson's Disease
Objective/Rationale:
Mutations in the LRRK2 gene are a common cause of familial and sporadic Parkinson’s disease. The LRRK2 protein can function as a kinase in vitro and certain familial mutations may... -
Understanding LRRK2 Biology, 2009Functional Analysis of LRRK2
Objective/Rationale:
LRRK2 is a gene that, when not working properly, causes Parkinson’s disease. However, the function of this large gene and its involvement in the disease process is virtually...
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