The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutics Development Initiative, 2006Develop Engineered Zinc Finger Protein Transcriptional Activators of the Glial Cell Line-Derived Neurotrophic Factor (GDNF) Gene as a Potential Therapy for Parkinson's Disease
Engineered zinc finger protein transcription factors (ZFP TFs) are an emerging class of molecules with the potential for broad therapeutic impact in the treatment of human disease. ZFP TFs function by...
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Community Fast Track, 2006Investigating Defects in Mitochondrial Functions, Transport, Fusion/Fission in LRRK2 Pre-clinical ModelsThe study of genetic forms of Parkinson’s disease is important for revealing the mechanisms of pathogenesis, and for future therapeutic developments. LRRK2 is the recently identified gene for Park8...
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Target Validation, 2006Identification of therapeutics that protect against toxins and genes implicated in Parkinson’s disease via the Forkhead-mediated transcription pathway
Loss of dopaminergic neurons is one of the cardinal features of Parkinson’s disease. Medications that can delay or prevent dopaminergic loss could be beneficial in treating PD, but the optimal...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2006Generation of Midbrain Dopamine Neurons from Human ES Cells by Forced Expression of Lmx1a
Drs. Ericson and Perlmann have identified two key transcription factors (Lmx1a and Msx1) that regulate early development of dopamine neurons and can induce nearly 90% ‘authentic’ dopamine neurons when...
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Biomarkers, 2005Epigenetic Regulation of the alpha-synuclein Gene as a Biomarker of Susceptibility to PD
Available genetic information in Parkinson's disease does not account for all phenomena in the clinical expressivity of the disease. For example, in the Contursi kindred with the A53T substitution in...
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Biomarkers, 2005Biomarkers in Human Cerebrospinal Fluid
This proposal involves confirmatory as well as discovery-type proteomic analyses of protein profiles in the human cerebral spinal fluid (CSF) obtained from patients with Parkinson's disease (PD) at...

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