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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2013
    Longitudinal Characterization of G2019S Models: Physiological and Behavioral Analyses of Dopamine and Glutamate Systems

    Objective/Rationale:
    It is likely in disease states that brain cells suffer long periods of dysfunction before they die. By studying the early effects of Parkinson’s disease (PD) gene mutations upon...

  • LRRK2 Pharmacodynamic Assays, 2013
    Monocyte Monitoring in LRRK2-associated Parkinson’s Disease

    Objective/Rationale:
    LRRK2 variants significantly contribute to the development of familial and sporadic Parkinson’s disease (PD). However, it is not yet understood how LRRK2 mutations cause cellular...

  • Research Grant, 2013
    Evaluation of a LRRK2 Inhibitor in the Partial 6-OHDA-lesioned Model of Parkinson’s Disease

    Objective/Rationale:
    Mutations in the LRRK2 gene are the most common cause of familial Parkinson’s disease (PD). The existing human genetic, cell-based and model data suggest that LRRK2 kinase...

  • Research Grant, 2013
    Using Whole Genome Sequencing Data from LRRK2 Families to Identify Novel Rare Variants of LRRK2-associated Parkinson’s Disease

    Objective/Rationale:
    The age of onset and penetrance (likelihood of disease) of individuals with the LRRK2 G2019S mutation varies considerably, the latter ranging in some families from as high as 100...

  • Cognition Biomarkers, 2013
    Validation of Novel and Traditional Quantitative EEG Biomarkers

    Objective/Rationale:
    Cognitive problems commonly add to the disability of the motor symptoms of Parkinson’s disease (PD), but there are no highly effective treatments for cognitive dysfunction in PD...

  • LRRK2 Challenge, 2013
    Physiological Role of Lysosomal LRRK2 in the Regulation of CMA

    Objective/Rationale:
    Brain cells rely on very efficient surveillance systems to identify defective components and break them apart to avoid accumulation and toxicity. Research has shown that in the...

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