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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2013
    Lung Tissue Model

    Study Rationale:
    Organovo will leverage its tools and expertise as a 3D biology company to construct a lung model suitable for the screening of certain pharmaceutical compounds. Robust lab-based lung...

  • Research Grant, 2013
    Evaluation of the RXR Agonist Compound IRX4204

    Study Rationale:
    Drugs that activate the retinoid X nuclear receptor (RXR) have been reported to promote survival of dopaminergic neurons in previously published pre-clinical studies. IRX4204 is a...

  • LRRK2 Cohort Consortium, 2013
    Gender Differences in LRRK2 Mutation and Non-LRRK2 Mutation PD, and Expression of LRRK2 Mutations

    Objective/Rationale:
    In Western populations, men are approximately 1.5 times more likely to develop Parkinson’s disease (PD) than women. Furthermore, epidemiologic and clinical features of PD vary...

  • Cognition Biomarkers, 2013
    [18F]flubatine: A Novel Biomarker of Cognition in Parkinson's Disease

    Objective/Rationale:
    Mild cognitive impairment and dementia are frequent symptoms of moderate to advanced Parkinson’s disease (PD). Brain positron emission tomography (PET) study findings confirm post...

  • Research Grant, 2013
    CLFB-113: MLK3 Inhibition in Pre-clinical Models of Parkinson's Disease

    Objective/Rationale:            
    Previously inhibitors of mixed lineage kinase 3 (MLK3) showed great promise for treatment of Parkinson’s disease in pre-clinical models, but interest in this area...

  • Clinicopathological Correlations for PD, 2012
    Identification of Alpha-synuclein Molecular Forms Correlating with Clinicopathology

    Promising Outcomes of Original Grant:
    We have developed a sensitive method for profiling alpha synuclein and its processed forms (“alpha synucleome”) from minimal clinical model brain tissue using...

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