The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2022Using “Nanobodies” to Prevent Formation of Intracellular Alpha-synuclein Aggregates
Study Rationale: The aggregation of a structurally abnormal form of the protein alpha-synuclein appears to be responsible for the initiation and progression of Parkinson’s disease (PD). In previous...
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, 2021Evaluating Patient-reported Outcome Assessment in Early Parkinson’s Disease
Study Rationale: There are currently no validated tools for assessing functional changes in people at the earliest clinical stages of Parkinson’s disease (PD). Available approaches lack sufficient...
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GBA Biology and Therapies, 2019Resolving the Pathophysiology of Parkinson's Disease with GBA Mutations
Study Rationale:
Mutations in the GBA gene are the greatest genetic risk factor for developing Parkinson’s disease (PD). We will systematically examine pathophysiological pathways in PD patients with... -
Research Grant, 2016GBA Meta-analysis Initiative: Charting a Path to Success for Clinical Trials in Patients with GBA-PD
Promising Outcomes of Original Grant:
We ascertained the associations between GBA mutations and cognitive and motor outcomes in seven large cohorts representing 2,304 patients with PD (including 221... -
Research Grant, 2016Novel Quantification in Parkinson’s Disease Neurochemical Imaging
Promising Outcomes of Original Grant:
We hypothesized in the original funded grant that evaluation of texture and variability, beyond conventional averaging of voxel (element of space) intensities... -
Therapeutic Pipeline Program, 2014Development of a mGluR4 Therapeutic for Parkinson's Disease
Study Rationale:
One of the major objectives for the development of new treatments for Parkinson’s disease is to find alternatives to the stimulation of the dopaminergic system through levodopa and...
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Our funding programs support basic, translational and clinical research from academia and industry.