The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Neurotrophic Factors Challenge, 2012Pre-clinical Validation of a Nurr1 Agonist for Neuroprotection in Parkinson’s Disease
Objective/Rationale:
Studies in PD patients have shown that increased cellular levels of α-syn are associated with reduced levels of Nurr1, and that mutations in the Nurr1 gene that have...
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Resource: Utilizing Samples from the Arizona Parkinson’s Dis, 2012Neurotrophic and Autophagic Markers in Parkinson’s Disease: Implications for Disease-modifying Strategies
Objective/Rationale:
GDNF is a potent survival factor for dopamine (DA) neurons, effective in standard neurotoxin models of PD, but recent studies show that GDNF is unable to rescue DA...
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Rapid Response Innovation Awards, 2012Evaluation of the Effects of Human Cell Derived GM1 Ganglioside in the MPTP Lesioned Pre-clinical Model of Parkinson's Disease
Objective/Rationale:
The objective of this study is to evaluate the effects of human cell derived GM1 (hGM1) ganglioside in the treatment of a pre-clinical model of Parkinsons disease (PD)... -
Dyskinesia LEAPS, 2012Development of L-745,870, a Selective D4 Receptor Antagonist, for the Treatment of Levodopa-induced Dyskinesia
Objective/Rationale:
In the 1980s and 90s a novel drug, L-745,870 was developed for the treatment of psychosis in schizophrenia. L-745,870 has excellent characteristics for a drug, and a selective... -
MJFF Research Grant, 2012Development of Nurr1-RXR Heterodimer Selective Agonists for Parkinson's Disease
Promising Outcomes of Original Grant:
We hypothesized that Nurr1 could be targeted indirectly with small molecules through other nuclear hormone receptors, and that such compounds would have... -
Alpha-synuclein Biology Challenge, 2012Alpha-synuclein as a Major Regulator of Iron Homeostasis
Objective/Rationale:
Alpha-synuclein is a key protein involved in Parkinson’s disease. Attempts have been made with drugs to lower the amount of this protein in the brain as a...
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Our funding programs support basic, translational and clinical research from academia and industry.