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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • LRRK2 in the Immune System, 2012
    Investigation of Neuroinflammation in LRRK2 Mutation Carriers Using Positron Emission Tomography

    Objective/Rationale:             
    There is evidence that LRRK2 mutation may alter the immune response in such as way as to potentiate neuroinflammatory responses to external triggers, with a...

  • Rapid Response Innovation Awards, 2012
    Targeting of 5-HT1A and 5-HT2A Receptors Against Levodopa-induced Dyskinesia

    Objective/Rationale:              
    Levodopa continues to be the gold-standard therapy for patients with Parkinson’s disease (PD). Unfortunately, effective long-term treatment is beset by abnormal...

  • Biomarker Development, 2012
    VILIP-1 as Diagnostic and Prognostic Biomarker for Parkinson's Disease

    Objective/Rationale:             
    Novel biomarkers are key for successful clinical development of Parkinson’s therapies. In Alzheimer’s disease the calcium sensing protein VILIP-1 (visinin-like...

  • Therapeutics Development Initiative, 2012
    Potential of Novel Insulin Sensitizers to Treat Dyskinesia

    Objective/Rationale:             
    The goal of this project is to determine whether the mTOT insulin sensitizer, MSDC-0160, can both prevent (when given at the same time) or reverse (when given later)...

  • MJFF Research Grant, 2012
    Non-kinase Targets in LRRK2 Biology

    Objective/Rationale:             
    We aim to understand how mutations in one gene, LRRK2, lead to Parkinson’s disease. We will do this by focusing on one region of the protein that has not had much...

  • Rapid Response Innovation Awards, 2012
    Modulation of the CD40/CD40-Ligand Neuroinflammation Pathway in Parkinson's Pre-Clinical Models

    Objective/Rationale:             
    In PD and PD-related models, neuroinflammation has been well documented. However, it is still unknown if neuroinflammation is a cause, contributor, or bystander in PD...

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