The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
-
Rapid Response Innovation Awards, 2010Down-regulation of GDNF Signaling in the Alpha-synuclein Model of PD: Implications for the Use of GDNF in Neuroprotective Therapy
Objective/Rationale:
GDNF is currently the most effective, and best studied, survival factor acting on dopamine neurons (the neurons that die in Parkinson´s disease, PD). Infusion of GDNF into the... -
Rapid Response Innovation Awards, 2010Identification of Small-molecule Stabilizers of DJ-1: Biophysical and Cellular Validation
Objective/Rationale:
The goal of our project is to develop an approach to treat PD by stabilizing wild-type dimeric DJ-1 with a small molecule. We hypothesize that this approach will lead to an... -
Target Validation, 2010Does the Ubiquitin Ligase, Nedd4, Protect Against Alpha-Synucleinopathy?
Objective/Rationale:
The cellular mechanisms that normally limit accumulation of alpha-synuclein are unclear. We have found that the enzyme, Nedd4, tags alpha-synuclein for destruction in lysosomes... -
Rapid Response Innovation Awards, 2010Genetic Dissection of Parkinson's Disease Vulnerable Dopaminergic Neurons Population
Objective/Rationale:
There is a clear heterogeneity in the susceptibility of dopamine neurons to Parkinson’s disease. Indeed, neurons of the substancia nigra ventral tier are specifically lost in... -
MJFF Research Grant, 2010Clinical Assessment of Patients with PD Who Underwent DAT Scan and FDG PET at the Early Stages of Their Extra-Pyramidal Disorder as Part of Their Initial Workup
Objective/Rationale:
Ashkenazi Jewish PD patients in Israel have a 14% chance of carrying the G2019S LRRK2 mutation and 18% of carrying mutations in the GBA gene. Little is known on the association... -
MJFF Research Grant, 2010Delayed Start Assessment of Progranulin in a Progressive Rodent Model of Parkinson’s Disease
Promising Outcomes of Original Grant:
In preliminary development work, we demonstrated the capacity of the protein progranulin to protect against disease development in several pre-clinical model...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.