The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutics Development Initiative, 2010Novel, Selective and Potent Brain-penetrant Small Molecule Inhibitors of Cytosolic Hsp90
Objective/Rationale:
Our objective is to develop novel drug candidates as therapeutics for Parkinson's disease by selectively targeting and inhibiting the heat shock protein-90 (Hsp90) in the brain... -
Therapeutics Development Initiative, 2010Development of a Zinc Finger Protein Therapeutic for the Potential Treatment of Parkinson's Disease
Objective/Rationale:
Engineered zinc finger protein transcription factors (ZFP TFs) can be designed to specifically increase the level of a therapeutically important protein from its native gene in a... -
Biomarkers, 2010Optimizing Biochemical Biomarkers for PD Research
Objective/Rationale:
A biochemical biomarker is a chemical in bodily fluids (e.g. blood, cerebrospinal fluid, urine, etc.) that may be helpful in detecting Parkinson’s disease (PD) or in measuring the... -
Biomarkers, 2010Oxidized DJ-1 as a Biomarker for Parkinson's Disease
Objective/Rationale:
Mutations in the DJ-1 gene are associated with an early-onset familial form of PD and DJ-1 protein has been shown to be decreased in the CSF of sporadic PD compared to controls. ... -
Target Validation, 2010Pharmacological PHD Inhibition as a Potential PD Neuroprotectant Therapy
Objective/Rationale:
A growing body of evidence suggests that iron dysregulation may contribute to neurodegeneration associated with Parkinson’s disease (PD). Recent work from our laboratory suggests... -
Target Validation, 2010VEGF-B - A New Neurotrophic Factor for Treatment for Parkinson's Disease
Objective/Rationale:
We discovered that the vascular endothelial growth factor, VEGF-B, acts as a natural response of brain cells to a neurotoxin that produces Parkinson’s disease in pre-clinical...
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Our funding programs support basic, translational and clinical research from academia and industry.