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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • PPMI Sample Request, 2014
    Whole Blood RNA Biomarkers of Parkinson’s Disease

    Objective/Rationale:
    When a Parkinson’s disease patient first experiences motor symptoms, most of the neurons in the part of the brain affected by the disease have already died and therefore the...

  • Resource: Utilizing DATATOP Biospecimens, 2011
    Validation of Alpha-synuclein Oligomers as Biomarker for Parkinson’s Disease

    Objective/Rationale:
    We have reported recently higher levels of α-synuclein oligomers species in cerebral spinal fluid (CSF) from patients clinically diagnosed with Parkinson’s disease (PD) versus...

  • Rapid Response Innovation Awards, 2007
    Methylphenidate for the Treatment of Gait Impairment in Parkinson's Disease

    Objective/Rationale:
    The objective of this study is to explore the effects of methylphenidate on the gait of patients with Parkinson’s disease who are experiencing shuffling and freezing...

  • Clinical Intervention Awards, 2007
    The PARKFIT Study: Effectiveness of an Active Lifestyle Promotion Program for Patients with Parkinson’s disease

    Objective/Rationale:
    Parkinson's patients are inclined toward a sedentary lifestyle. This is due to a combination of both physical handicaps (e.g. walking difficulties) and mential impairments (e.g...

  • Research Grant, 2010
    Longitudinal Follow-Up of Clinical and Neuroimaging Signs and Biomarkers in Symptoms & Side Effects and aSymptoms & Side Effects LRRK2 Mutation Carriers in Comparison to Idiopathic PD and Controls

    Objective/Rationale
    Parkinson’s disease (PD) is a common neurodegenerative disease that leads to progressive motor impairment as well as autonomic and cognitive disturbances. The cause of most of...

  • Rapid Response Innovation Awards, 2013
    Topography of Vulnerability to Alpha-synuclein Fibrils in the Cerebral Cortex

    Objective/Rationale:             
    In Parkinson’s disease, the neocortex (outer layer of the brain’s cerebral hemispheres, made of six layers) is less vulnerable than the allocortex (fewer than six...

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