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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2022
    Self-reported Perceptions and Self-reported Outcomes on Motor and Non-motor Symptoms in the Parkinson's Disease Continuum: A Systematic Review of Mixed Methods

    Study Rationale: People are unique in the way they experience quality of life. Throughout the progression of Parkinson's disease, patients and their care partners have different perceptions of motor...

  • Parkinson’s Pathway Molecular Data Analysis Program, 2022
    Developing Biomarker Signatures of Parkinson’s Disease Using a Novel Progression Model

    Study Rationale: Although Parkinson’s disease (PD) affects individuals differently, there are groups of people with PD who share similar features and whose disease changes similarly over time...

  • Target Advancement Program, 2022
    Assessing the Neuroprotective Factor REST/NRSF as a Therapeutic Target for Parkinson’s Disease

    Study Rationale: Evidence suggests that a regulatory factor called REST (also known as NRSF) could promote the survival of neurons in neurodegenerative conditions. Studies have shown that this...

  • Target Advancement Program, 2022
    Assessing the Ability of Neuronal Modulators to Treat or Modify the Motor Symptoms of Parkinson’s Disease

    Study Rationale: The dopamine-producing cells that are lost in Parkinson’s disease (PD) express a unique type of cell-surface protein called the M5 muscarinic acetylcholine receptor. The presence of...

  • Expanding Biological Understanding of Parkinson's Disease, 2022
    Investigation of the Role of PINK1 in Regulating Immune Signaling in Mitochondria

    Study Rationale: Evidence is accumulating that the Parkin and PINK1, gene products whose activities are altered in Parkinson’s disease (PD), play a role in immune signaling. We previously identified a...

  • Therapeutic Pipeline Program, 2022
    Developing an Assay to Identify Glucocerebrosidase-enhancing Chaperones for the Treatment of Parkinson’s Disease

    Study Rationale: Discovering genes associated with Parkinson’s disease (PD) facilitates the design of new treatment strategies for this disorder. Mutations in the glucocerebrosidase gene (GBA1) are...

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