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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Target Validation, 2007
    Development of Lentiviral DN-TNF Vectors: A Novel Anti-inflammatory Gene Therapy to Block Nigrostriatal Degeneration

    Objective/Rationale:

    A growing number of epidemiological and experimental animal studies implicate neuroinflammatory mechanisms in the progressive death of midbrain dopamine (DA) neurons in Parkinson’s...

  • Clinical Intervention Awards, 2007
    Serotonin and Sleep Disordered Breathing in Parkinson Disease

    Objective/Rationale:
    Sleep related problems are a major cause of impairment in Parkinson's disease. Recent studies indicate a high incidence of a disabling sleep disorder – sleep disordered breathing...

  • Clinical Intervention Awards, 2007
    The PARKFIT Study: Effectiveness of an Active Lifestyle Promotion Program for Patients with Parkinson’s disease

    Objective/Rationale:
    Parkinson's patients are inclined toward a sedentary lifestyle. This is due to a combination of both physical handicaps (e.g. walking difficulties) and mential impairments (e.g...

  • Clinical Intervention Awards, 2007
    Helicobacter Pylori Eradication and Motor Fluctuations in Parkinson's Disease

    Objective/Rationale:
    Helicobacter pylori is a common bacterial infection often associated with disorders of the gastrointestinal tract. Treatment of H. pylori in patients with Parkinson’s disease has...

  • Clinical Intervention Awards, 2007
    NH004 Films for Sialorrhea in PD Patients (2007)

    Objective/Rationale:
    The goal of the research is to advance the clinical development of NH004 for the control of sialorrhea (excessive drooling or uncontrolled salivation). NH004 is a dissolving film...

  • Clinical Intervention Awards, 2007
    The role of striatal serotonergic terminals in L-dopa induced-dyskinesia in PD patients: An in vivo PET study

    Objective Rationale:
    In this project the team will explore a possible mechanism responsible for a common complication of long-term L-dopa treatment in Parkinson’s disease (PD), L-dopa induced...

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