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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Biomarkers, 2007
    Validation of CSF Alpha-synuclein as a Biomarker for Parkinson's disease

    Objective/Rationale:
    Accumulation of alpha-synuclein within certain nerve cells represents one of the hallmarks of classical Parkinson disease. Our team recently discovered that alpha-synuclein levels...

  • Biomarkers, 2007
    Multimodal MRI Markers for Parkinson's Disease

    Objective/Rationale:
    The assessment of Parkinson’s disease is currently based on clinical symptoms that make an accurate diagnosis challenging, especially early on, when subtle impairment of movement...

  • Biomarkers, 2007
    Isoforms of Alpha-synuclein as Biomarkers for Diagnosis and Progression of Parkinson's Disease

    Objective/Rationale:
    Alpha-synuclein is involved in the development and progression of Parkinson’s disease unequivocally. Our preliminary data has suggested that there were several alpha-synuclein...

  • LEAPS, 2007
    Therapeutic Development of siRNA Targeting Alpha-Synuclein

    Objective/Rationale:
    Clinical, genetic and experimental evidence supports an association between alpha-synuclein expression and Parkinson’s disease. This toxicity is likely to be attenuated by...

  • Target Validation, 2007
    Targeting Urate: A Molecular Correlate of Both Risk and Progression in PD

    Objective/Rationale:
    Urate (a natural antioxidant, caffeine analog and DNA metabolite) is the first molecule linked to both the risk of typical Parkinson’s disease and its rate of progression. Higher...

  • Rapid Response Innovation Awards, 2007
    Potential Utility of Novel CNS-active Experimental Therapeutics for Parkinson's Disease

    Objective/Rationale:
    Evidence suggests that overproduction of inflammatory molecules, called proinflammatory cytokines, from glial cells in the brain can contribute to nerve cell death and accelerate...

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