The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutics Development Initiative, 2006Develop Engineered Zinc Finger Protein Transcriptional Activators of the Glial Cell Line-Derived Neurotrophic Factor (GDNF) Gene as a Potential Therapy for Parkinson's Disease
Engineered zinc finger protein transcription factors (ZFP TFs) are an emerging class of molecules with the potential for broad therapeutic impact in the treatment of human disease. ZFP TFs function by...
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Community Fast Track, 2006Investigating Defects in Mitochondrial Functions, Transport, Fusion/Fission in LRRK2 Pre-clinical ModelsThe study of genetic forms of Parkinson’s disease is important for revealing the mechanisms of pathogenesis, and for future therapeutic developments. LRRK2 is the recently identified gene for Park8...
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Community Fast Track, 2006The Role of Serotonin Neurons in the Induction of Dyskinesia in Grafted and L-DOPA-primed Animals
Levodopa, which is the most commonly used medication for patients with Parkinson's disease, is a beneficial therapy, but as the disease progresses it can be the cause of debilitating involuntary...
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MJFF Research Grant, 2006A Phase II Clinical Trial of Neurturin (NTN) Gene Therapy for PD
Objective/Rationale:
Neurotrophic factors including neurturin (NTN) have been shown to effectively augment the function and prevent the death of dopaminergic nigrostriatal neurons in animal models of... -
MJFF Research Grant, 2006The Unified Dyskinesia Rating Scale (UDysRS): Clinimetric Testing Program
In Parkinson’s disease, one of the most troubling clinical issues for prevention and management is drug-induced dyskinesia. Dyskinesias are abnormal and involuntary movements that relate in part to...
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MJFF Research Grant, 2006PDGene
Parkinson’s disease is a genetically complex and heterogeneous disorder. To date, mutations in five genes have been identified to cause early-onset parkinsonism, which typically follows Mendelian...
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Our funding programs support basic, translational and clinical research from academia and industry.