The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Aligning Science Across Parkinson's, 2020Cellular Mechanism of LRRK2 in Health and Disease
Study Rationale:
Leucine Rich Repeat Kinase 2 (LRRK2), is the most commonly mutated gene in inherited forms of Parkinson’s disease (PD). The LRRK2 gene codes for a protein kinase, an enzyme that adds... -
Aligning Science Across Parkinson's, 2020IMPACT-PD - Implications of Polyamine and Glucosylceramide Transport in Parkinson’s Disease
Study Rationale:
Mutations in the genes ATP13A2 (PARK9) and ATP10B trigger Parkinson’s disease (PD) and cause dysfunction of lysosomes, the recycling compartments of the cell. We explained these... -
Aligning Science Across Parkinson's, 2020Parkinson5D: Deconstructing Proximal Disease Mechanisms across Cells, Space and Progression
Study Rationale:
Genome-wide association studies (GWAS) have unequivocally linked thousands of noncoding variants in 90 independent GWAS signals to susceptibility for common, genetically complex... -
Aligning Science Across Parkinson's, 2020Dissecting Genetic Interactions of Parkinson’s Disease-associated Risk Loci
Study Rationale:
Parkinson’s disease can have multiple complex causes, including genetic and environmental, that are not fully understood. We will combine modern genetic and human stem cell-based... -
Aligning Science Across Parkinson's, 2020Mapping the PD Brain: Oligomer-driven Functional Genomics
Study Rationale:
To determine the molecular and cellular process that lead to PD, a powerful approach is to single out and study the cells where the disease originates. To achieve this goal, we use... -
Aligning Science Across Parkinson's, 2020Understanding Inherited and Acquired Genetic Variation in Parkinson’s Disease through Single-cell Multi-omics Analyses
Study Rationale:
Parkinson’s disease (PD) is a disorder that not only affects the function of our brain, but also of our gut, which are both complex tissues composed of functionally diverse types of...
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Our funding programs support basic, translational and clinical research from academia and industry.