MJFF Publications

The Michael J. Fox Foundation continually strives to communicate our scientific progress with the research community — through posters and presentations at meetings, in peer-reviewed scientific publications and with white paper reports.

Year Published

LRRK2 Kinase Inhibitors of Different Structural Classes Induce Abnormal Accumulation of Lamellar Bodies in Type II Pneumocytes in Non-Human Primates but are Reversible and Without Pulmonary Functional Consequences

October 21, 2015

Marco A.S. Baptista1, Kalpana M. Merchant1, Sakshi Bharghava2, Diane Bryce3, Michael Ellis3, Anthony A. Estrada4, Matthew Fell3, Reina N. Fuji4, Paul Galatsis2, Sue Hill3, Warren D. Hirst2,…

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Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

February 4, 2015

Inhibition of the kinase activity of leucine-rich repeat kinase 2 (LRRK2) is under investigation as a possible treatment for Parkinson's disease. However, there is no clinical validation as yet, and…

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Use of an Online Portal to Facilitate Clinical Trial Recruitment: A Preliminary Analysis of Fox Trial Finder (Article)

January 1, 2015

Journal of Parkinsons Disease An evaluation of Fox Trial Finder -- MJFF's online tool that matches eligible volunteers to local, recruiting clinical trials -- characterizes potential research…

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The hTH-GFP Reporter Rat Model for the Study of Parkinson's Disease

December 2, 2014

Lorraine Lacovitti, Xiaotao Wei, Jingli Cai, Eric W. Kostuk, Ruihe Lin, Alexander Gorodinsky, Philip Roman, Gretchen Kusek, Sonal S. Das, Audrey Dufour, Terina N. Martinez, and Kuldip D. Dave …

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Characterization, comparison, and cross-validation of in vivo alpha-synuclein models of parkinsonism.

November 17, 2014

Terina. N. Martinez1, Michael Sasner2, Mark T. Herberth3, Robert C. Switzer III4, S.O. Ahmad5, Kelvin C. Luk6, Sylvie Ramboz7, Andrea E. Kudwa7, Deniz Kirik8, Joe Flores8, Ronald J. Mandel9,…

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Therapeutic Development Paths for Cognitive Impairment in Parkinson's Disease: Report of a Regulatory Roundtable

July 2, 2014

Journal of Parkinsons Disease Cognitive impairment is a common occurrence in Parkinson's disease (PD), although the severity and specific presentation varies across patients. Initial deficits,…

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Overcoming obstacles to repurposing for neurodegenerative disease

June 24, 2014

Annals of Clinical and Translational Neurology Repurposing Food and Drug Administration (FDA)-approved drugs for a new indication may offer an accelerated pathway for new treatments to patients but…

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Articles authored by Rachel Dolhun, MD, a movement disorder specialist on staff at MJFF, offer a practical review of topics related to Parkinson's disease for practicing clinicians.

Year Published

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MJFF Publications

LRRK2 Kinase Inhibitors of Different Structural Classes Induce Abnormal Accumulation of Lamellar Bodies in Type II Pneumocytes in Non-Human Primates but are Reversible and Without Pulmonary Functional Consequences

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

Use of an Online Portal to Facilitate Clinical Trial Recruitment: A Preliminary Analysis of Fox Trial Finder (Article)

The hTH-GFP Reporter Rat Model for the Study of Parkinson's Disease

Characterization, comparison, and cross-validation of in vivo alpha-synuclein models of parkinsonism.

Therapeutic Development Paths for Cognitive Impairment in Parkinson's Disease: Report of a Regulatory Roundtable

Overcoming obstacles to repurposing for neurodegenerative disease

Breaking Research Updates