To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Alpha-Synuclein Preformed Fibril Protein*
Aggregated alpha-synuclein protein intended for use in synuclein seeding experiments.
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AAV Scrambled Control 3xmiR/GFP Plasmid
Viral transgene plasmid used in the AAV scrambled control 3xmiR/GFP viral vector available through Charles River Labs (see viral vector section). This plasmid is available to non-profit groups only. RRID:Addgene_194249
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SNCA Triplication iPSC line set*
iPSC line derived from a patient with the SNCA triplication mutation. Corrected lines with normal SNCA expression levels and TdTomato reporter KI versions of the lines will also be available. These lines were generated and kindly deposited by Vik Khurana into the MJFF Sponsored Tools Program.
Expected Availability: Mid 2024
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LRRK2 N2081D KI Mouse*
Mice with the N2081D mutation in LRRK2. Model was generated and deposited by Dr Zhenyu Yue at the Icahn School of Medicine at Mount Sinai through the MJFF Sponsored Tools Program.
Estimated Availability: Late 2024
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Parkin R275W KI Mouse*
Mice with the R275W mutation in Parkin. Model was generated and deposited by Dr David Komander at Walter and Eliza Hall Institute of Medical Research through the MJFF Sponsored Tools Program.
Estimated Availability: Late 2024
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Parkin K161N KI Mouse*
Mice with the K161N mutation in Parkin. Model was generated and deposited by Dr David Komander at Walter and Eliza Hall Institute of Medical Research through the MJFF Sponsored Tools Program.
Estimated Availability: Late 2024
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Conditional R1441G KI Mouse*
Mice designed for conditional knockin of the LRRK2 R1441G mutation. Model was generated and deposited by Dr Dario Alessi at the University of Dundee through the MJFF Sponsored Tools Program.
Estimated Availability: Early 2024
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Human iPSC with HiBit-tagged VPS35*
Human iPSC line with HiBiT tag on the VPS35 protein and inducible LgBiT expression for live cell imaging and quantitation. Cell line was developed and kindly shared by Dr. Tom Durcan at McGill University through the MJFF Sponsored Tools Program.
Estimated Availability: Mid 2024
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic