![Illustrated close up of DNA.](/sites/default/files/styles/hero_xl/public/images/hero/Artboard1-80.jpg?h=1771c8c6&itok=tpxriJzH)
![Illustrated close up of DNA.](/sites/default/files/styles/hero_xl/public/images/hero/Artboard1-80.jpg?h=1771c8c6&itok=tpxriJzH)
To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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AAV1/2-CAG-Mouse SNCA 3xmiR/GFP
CNS optimized viral vector (AAV1/2 pseudotype) encoding GFP and 3XmiR to alpha-synuclein for specific knockdown of WT mouse a-syn and common pathogenic mutant forms (A53T, A30P, E46K). Scrambled Control 3xSCRmiR/GFP available as a control in Reporter section and AAV Mouse SNCA 3xmiR/GFP plasmid available in the Plasmid section.
Generated as part of the Industry Tools Consortium.
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LRRK1/2 Double KO Rat*
Double knockout of the genes encoding LRRK1 and LRRK2 in the Long Evans Hooded rat strain. RRID:RGD_7241053
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PINK1 KO Rat*
Homozygous rat knockout of Pink1 (PTEN-induced putative kinase 1) in the Long Evans Hooded rat strain. RRID:RGD_7241054
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LRRK1 KO Rat*
Knockout of the gene encoding LRRK1 in the Long Evans Hooded rat strain. RRID:RGD_7241057
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DJ-1 proteins (recombinant proteins generated in a mammalian-optimized expression system)
The following versions of recombinant DJ-1 protein generated using a mammalian-optimized expression system are available:
- His-tagged DJ-1
- TEV-cleaved DJ-1
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DJ-1 proteins (recombinant proteins generated using an E. Coli expression system)
The following versions of recombinant DJ-1 protein generated using an E. coli expression system are available:
- Untagged DJ-1
- His-tagged DJ-1
- Oxidized DJ-1
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HdAd5 3xFLAG-LRRK2 (G2385R)
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged LRRK2 with the G2385R mutation. HdAd5 FLAG-TK available as a control in Reporter section.
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Cell line stably expressing mutant LRRK2 D2017A/G2019S (KI) (Type: Raw 264.7 macrophages)
RAW 264.7 macrophage cell line expressing a D2017A and G2019S mutation in LRRK2 knocked into the endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
We were unable to generate this cell line due to technical difficulty and have discontinued production.
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.