Esther Sammler is a clinician scientist at the University of Dundee in the MRC Protein Phosphorylation and Ubiquitylation Unit. She holds a Scottish Senior Clinical Academic Fellowship and her lab is focused on translating basic research findings into the clinical context, working with clinical biosamples and multimodal stratification of patients including genetics, clinical phenotypes and biochemical function with the goal of better understanding Parkinson’s disease (PD). Her particular interest is in LRRK2 kinase signalling in health and disease. As a neurologist, she looks after people with PD and runs clinical trials. Dr. Sammler obtained her medical degree from the Ludwig-Maximillian’s-University in Munich, Germany and worked at the University of Heidelberg before relocating to Scotland. Her received her PhD (Signalling pathway of the E3 ligase subunit FBX07 and its role in hereditary Parkinsonism’ supervised by Professor Dario Alessi) in 2014 and she qualified as consultant neurologist in 2016.
Associated Grants
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Implementation and Validation of Lysosome-specific Tests of GCase Activity in Cell Lines and Human Peripheral Blood
2023
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Use of LRRK2 and Lysosomal Biomarker Signatures to Differentiate Idiopathic and Monogenetic Parkinson’s Disease
2021
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Studying Measures of LRRK2 Activation and Lysosomal Dysfunction in Parkinson's Disease
2018