Valentina Escott-Price has been with the division of psychological medicine and clinical neurosciences at the Cardiff University since 2002. Her main research interest is to deploy the new opportunities afforded by technological advances and large sample sizes to aid in the identification of new risk genes and biological pathways for complex disorders, and to undertake integrative analyses to provide additional biological meaning to the basic genetic data. Aided by her deep understanding and extensive expertise in dementia research, and by her solid training in mathematics, she has developed powerful and accurate models and analyses based on national and international resources of deeply phenotyped data with millions of genetic variants. Her recent research generated a world-wide interest, as she was the first to show that Alzheimer’s disease has a polygenic component which can be a valuable research tool complementing experimental designs, including preventative clinical trials and high/low risk clinical studies.