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Searching for Genes that Control Alpha-synuclein Levels in Parkinson's Disease
… can protect the brain from damage, as shown in multiple pre-clinical models with Parkinson's features. … therapeutic strategy for Parkinson's disease. The proposed systematic approach to finding genes that regulate …
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G. Sridhar Prasad, PhD
… Inc., where he was lead crystallographer and core member of multiple drug discovery programs, including schizophrenia … in building and implementing fragment-based technologies in multiple organizations including Merck and Metabasis. He is …
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Anna Quattropani, PhD
… optimizing drug-like small molecules with CNS exposure for multiple sclerosis and Alzheimer’s disease therapeutics. She … for progressive supranuclear palsy (O-GlcNAcase inhibitor), multiple sclerosis and an oxytocin receptor antagonist that …
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Dynamical interactions between basal ganglia structures and cerebral Cortex: an in Vivo Multi-site Recording Study
… we will obtain simultaneous electrical recordings from multiple sites in the basal ganglia of rodents. Rodents have … have been rendered Parkinsonian. Following this activity in multiple brain structures will allow us to determine how …
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Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in non-human primates
May 13, 2020
… Parkinson's disease (PD). Much evidence, accumulated from multiple experimental models, has suggested that α-syn plays … supporting the true multifactorial nature of PD, as multiple causes can induce a similar outcome regarding …
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Sheng Luo, PhD
… Disease Research Center (ADRC). He is also PI of multiple projects regarding novel latent variable modeling … faculty statistician in numerous clinical trials and multiple Data and Safety Monitoring Boards. …