The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Repositioning Drugs for PD, 2012Amitriptyline as a Dopamine Neuroprotective Therapy
Objective/Rationale:
The project proposes to repurpose the tricyclic antidepressant medication, amitriptyline (AMI), as a disease-modifying therapy for Parkinson’s disease (PD). AMI is an FDA-approved... -
Neurotrophic Factors Challenge, 2012Validation of IGF-1 as a Neuroprotective Agent in Pre-clinical Models of Parkinson’s DiseaseObjective/Rationale: IGF-1-mediated intracellular signaling pathways engage a wide range of potential survival mechanisms, the PI3K/Akt pathway and the ER stress response in particular, and it has...
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Rapid Response Innovation Awards, 2012Is Parkinson’s Disease a Low-grade Inflammatory Bowel Disease?
Objective/Rationale:
Central and peripheral inflammations are likely to be critical in the initiation and/or development of PD. Data from recent genetic studies suggest a link between PD and gut... -
Repositioning Drugs for PD, 2012Atomoxetine for Cognitive Impairment in Parkinson’s Disease
Objective/Rationale:
Parkinson’s disease (PD) causes well known motor symptoms of tremor, slowness and stiffness, but also leads to cognitive impairment. Research has shown that early loss of cells in... -
Research Grant Supplement, 2012Generation and Characterization of iPS Neurons from Genetic Parkinson’s Disease
Promising Outcomes of Original Grant:
The goal of the previous project was to establish iPS-derived neurons from patients with PINK1- and Parkin-linked familial forms of PD. We used the latest... -
Clinical Intervention Awards, 2012A Randomized Controlled Trial of Neurocognitive and Supportive Therapy Interventions for Individuals with Parkinson’s DiseaseObjective/Rationale: In the twenty-first century the motor symptoms of Parkinson’s disease (PD) are typically well-managed. The neurocognitive symptoms of Parkinson’s disease often result in...
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Our funding programs support basic, translational and clinical research from academia and industry.