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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Access to Data and Biospecimens, 2016
    MicroRNAs as biomarkers of the prodromal stage of Parkinson disease’

    Study Rationale:

    MicroRNAs (miRNAs) are small regulatory RNAs controlling gene expression. We have recently reported reduced  miRNAs levels in serum from Parkinson disease (PD) patients, and also from...

  • Research Grant, 2016
    Parkinson's Disease Genetics Sequencing Consortium

    Study Rationale:
    The Parkinson's Disease Genetics Sequencing Consortium (PDGSC) was established following a National Institute of Neurological Disorders and Stroke workshop in June 2014 and brings...

  • Research Grant, 2016
    Rab Detection Initiative and LRRK2 Detection Initiative Supplemental Support RDI, and LCC exosome replication

    Study Rationale:
    The LRRK2 detection initiative (LDI) and Rab detection initiative (RDI) are focused on developing techniques for the robust and sensitive detection of LRRK2, phospho-LRRK2, Rab and...

  • Research Grant, 2016
    LRRK2 Biomarker Initiative: Detection of LRRK2 in Cerebrospinal Fluid

    Study Rationale:
    Recent studies indicate the potential use of LRRK2 or LRRK2 phosphorylation (protein regulation) in biosamples as disease markers or as markers of response to novel therapeutics...

  • Research Grant, 2016
    Mechanisms of LRRK2 Membrane Association

    Promising Outcomes of Original Grant:
    We have verified that LRRK2 undergoes key changes that affect LRRK2 structure and LRRK2 membrane localization. We have generated a large set of LRRK2 variants...

  • Target Advancement Program, 2016
    LRRK2 Mutations and the Development of Therapeutic LRRK2 Inhibitors

    Study Rationale:
    Mutations in the leucine-rich repeat kinase 2 (LRRK2) protein can cause an inherited form of Parkinson's disease (PD). Understanding how these mutations cause PD is complicated, as...

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