The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2014Microvesicles: Biomarker and Vehicle for the Propagation of Pathological Forms of Alpha-synuclein
Study Rationale:
All living cells release extracellular vesicles composed of membrane proteins and lipids as well as components of the cell. These vesicles are important in cell-to-cell communication... -
Rapid Response Innovation Awards, 2014Role of Nicotinamide N-methyltransferase in Genetic Models of Parkinson’s Disease
Study Rationale:
There is mounting evidence linking the metabolism of the vitamin niacin to Parkinson’s disease (PD). The enzyme nicotinamide N-methyltransferase (NNMT), a key enzyme of the niacin... -
Rapid Response Innovation Awards, 2014Screening Assays for Restored Protein Trafficking
Study Rationale:
Protein trafficking is the process by which proteins are transported from where they’re made to where they’re needed inside cells. Defects in trafficking cause proteins to accumulate... -
Rapid Response Innovation Awards, 2014Alpha-synuclein Knock-down Peptides for Neuroprotection and Reversal of Pathology in a Model of Parkinson’s Disease
Study Rationale:
Protein misfolding and aggregation is likely to be a central mechanism in the neurodegenerative changes seen in Parkinson’s disease (PD). The Canadian partner in this project has... -
Research Grant, 2014Imaging Neuroinflammation in LRRK2 Models of Parkinson’s Disease
Objective/Rationale:
The mechanisms for the initiation and progression of the loss of dopamine (DA) neurons in Parkinson’s disease (PD) are still largely unknown. Increasing evidence indicates that... -
LRRK2 LEAPS, 2014Targeting Retromer Dysfunction: A Convergent Mechanism in Familial and Sporadic Parkinson’s Disease
Study Rationale:
Our goal is to understand how mutations in the gene LRRK2 can drive Parkinson’s disease (PD) risk. Our previous studies of neurons with mutant LRRK2 kinase have...
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Our funding programs support basic, translational and clinical research from academia and industry.