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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2014
    Microvesicles: Biomarker and Vehicle for the Propagation of Pathological Forms of Alpha-synuclein

    Study Rationale:
    All living cells release extracellular vesicles composed of membrane proteins and lipids as well as components of the cell. These vesicles are important in cell-to-cell communication...

  • Rapid Response Innovation Awards, 2014
    Role of Nicotinamide N-methyltransferase in Genetic Models of Parkinson’s Disease

    Study Rationale:
    There is mounting evidence linking the metabolism of the vitamin niacin to Parkinson’s disease (PD). The enzyme nicotinamide N-methyltransferase (NNMT), a key enzyme of the niacin...

  • Rapid Response Innovation Awards, 2014
    Screening Assays for Restored Protein Trafficking

    Study Rationale:
    Protein trafficking is the process by which proteins are transported from where they’re made to where they’re needed inside cells. Defects in trafficking cause proteins to accumulate...

  • Rapid Response Innovation Awards, 2014
    Alpha-synuclein Knock-down Peptides for Neuroprotection and Reversal of Pathology in a Model of Parkinson’s Disease

    Study Rationale:
    Protein misfolding and aggregation is likely to be a central mechanism in the neurodegenerative changes seen in Parkinson’s disease (PD). The Canadian partner in this project has...

  • Research Grant, 2014
    Imaging Neuroinflammation in LRRK2 Models of Parkinson’s Disease

    Objective/Rationale:
    The mechanisms for the initiation and progression of the loss of dopamine (DA) neurons in Parkinson’s disease (PD) are still largely unknown. Increasing evidence indicates that...

  • LRRK2 LEAPS, 2014
    Targeting Retromer Dysfunction: A Convergent Mechanism in Familial and Sporadic Parkinson’s Disease

    Study Rationale:                   
    Our goal is to understand how mutations in the gene LRRK2 can drive Parkinson’s disease (PD) risk. Our previous studies of neurons with mutant LRRK2 kinase have...

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