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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2013
    Alpha-Synuclein-Expression-Lowering Therapeutics: Initial Pre-Clinical Development

    Objective/Rationale:             
    Increased dosage of the alpha-synuclein gene is linked to Parkinson’s disease (PD). Out of 1,126 FDA-approved compounds and health supplements screened, we identified...

  • Rapid Response Innovation Awards, 2013
    BL-OG: A Novel, Minimally-Invasive and Homeostatic Method for Selective Regulation of Neural Dynamics in the Subthalamic Nucleus

    Objective/Rationale:             
    Altered neural activity in the subthalamic nucleus (STN) is believed to be key to Parkinson’s disease. Accordingly, deep-brain stimulation (DBS) delivered to the STN...

  • Biosample and Tissue Resource, 2013
    Relationship of Vitamin B12 Status and Parkinson's Disease

    Objective/Rationale:             
    Vitamin B12 deficiency can cause a number of neurological symptoms, including instability, neuropathy (which may cause numbness and tingling) and cognitive defects...

  • Research Grant, 2013
    Cutaneous Alpha-Synuclein Deposition — A Biomarker in Parkinson’s Disease

    Objective/Rationale:             
    There is an unmet need for a biomarker in Parkinson’s disease (PD). Accumulating evidence suggests that deposition of alpha-synuclein, the pathological hallmark of PD...

  • Rapid Response Innovation Awards, 2013
    Creation of the “BiSyn” Model: a Novel Tool to Monitor Alpha-synuclein Aggregation

    Objective/Rationale:             
    The cause of Parkinson’s disease (PD) is unknown. However, it has become clear that the abnormal aggregation of a neuronal protein called alpha-synuclein has an...

  • Biosample and Tissue Resource, 2013
    Alpha-synuclein Three Prime Untranslated Region (3’UTR) Modulation in Parkinson's Disease

    Objective/Rationale:             
    New technology shows that many genes are transcribed (the first step in genetic expression) as multiple, different forms of RNA (molecules that play a role in genetic...

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