The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
-
Access to Data & Biospecimens, 2017Klotho and Parkinson’s disease
Study Rationale:
Genetic studies have identified a powerful “aging suppressor gene”, Klotho, that may play a role in delaying age-related declines in cellular and tissue functioning...
-
Target Advancement Program, 2017Disruption of Pathological Protein-protein Interactions in Alpha-synuclein
Study Rationale:
The spread of alpha-synuclein (sticky protein that clumps in the brains of those with Parkinson's) occurs through a cell-to-cell prion-like (spreading) mechanism. Disrupting the... -
Therapeutic Pipeline Program, 2017Cell-Permeable Parkin Protein Suppresses Parkinson's Disease-associated Symptoms
Study Rationale:
The Parkin protein (encoded by the PARK2 gene that is linked to Parkinson's), has been shown to exert potent neuroprotective effects that could potentially be used to treat Parkinson's... -
Research Grant, 2017Promoting Mitochondrial Transport in Dopaminergic Neurons
Study Rationale:
Healthy mitochondria (powerhouses of the cell) are crucial to the survival of neurons, and poorly-functioning mitochondria are implicated in the neurodegeneration associated with... -
Target Advancement Program, 2017Preventing Misfolded Alpha-synuclein Accumulation
Study Rationale:
The pathological hallmark of Parkinson's disease (PD) is the widespread accumulation of cellular deposits (Lewy Bodies) comprised of clumps of a misfolded protein called alpha... -
Improved Biomarkers and Clinical Outcome Measures, 2017Regulation of the SNCA Gene in Parkinson's Disease
Study Rationale:
DNA methylation is a regulatory mechanism that can turn genes on or off within the cells in our body. In Parkinson's disease (PD), methylation near SNCA (a gene linked to PD) is lower...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.