The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2021Using Ketamine to Treat Depression in Parkinson’s Disease
Study Rationale:
Depression affects around half of people with Parkinson’s disease (PD). However, existing antidepressants are not effective in treating these symptoms in PD and new treatments are... -
Analysis of Patient-Reported Outcomes from Fox Insight, 2021Overcoming Underrepresentation to Improve Generalizability in Fox Insight
Study Rationale:
Fox Insight is an online clinical study that surveys over 25,000 people with Parkinson disease (PD) about their overall health, symptoms and well-being. Unfortunately, certain groups... -
Therapeutic Pipeline Program, 2021Targeting Brain-specific Stearoyl-CoA-Desaturase 5 (SCD5) as a Treatment for Parkinson’s Disease
Study Rationale:
Previous studies have shown that fat molecules called unsaturated fatty acids regulate the harmful effects that alpha-synuclein have on neurons. This protein forms a key part of Lewy... -
Therapeutic Pipeline Program, 2021Assessing the Potential of Low-Dose Carbon Monoxide Therapy in Parkinson’s Disease
Study Rationale:
Although carbon monoxide (CO) is commonly considered harmful, a growing body of research suggests that low doses of CO can stimulate physiologic processes that may protect against... -
Expanding Biological Understanding of PD, 2021Assessing Inhibition of NLRP3 to Reduce Brain Inflammation in Parkinson’s Disease
Study Rationale:
Recent studies indicate that brain inflammation caused by activation of a protein complex called the NLRP3 inflammasome worsens Parkinson’s disease (PD). Although multiple drugs that... -
Analysis of Patient-Reported Outcomes from Fox Insight, 2021Characterizing Impairment Trajectories in People with Parkinson’s Disease
Study Rationale:
Little is known about what causes individuals with Parkinson’s disease (PD) to develop symptoms, much less the genetic and non-genetic factors that influence these changes. In most...
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Our funding programs support basic, translational and clinical research from academia and industry.