The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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- Measuring Alpha-Synuclein in Extracellular Vesicles, 2025Measurement of Alpha-synuclein in Plasma Extracellular Vesicles after Automated Isolation
Study Rationale: Extracellular vesicles are small, membrane-enclosed packages that all cells release into the blood. Because the contents of these packages reflect that of the cells from which they...
- iPSC Phenotyping Environmental Exposure Program, 2025Assessing How Triplication of the Alpha-synuclein Gene Affects Electrophysiological and Mitochondrial Phenotypes in Neurons, Astrocytes and Microglia
Study Rationale: One common familial inherited form of Parkinson’s disease (PD) is caused by triplication of SNCA, the gene that encodes the protein alpha-synuclein. Alpha-synuclein forms toxic...
- Neuronal Synuclein Disease Endotypes 2024, 2025Using the Biopark Cohort to Study Neuronal Synuclein Disease Types
Study Rationale: To study the pathogenic processes underlying Parkinson’s disease (PD), we have recruited a cohort of several hundred people, including those with hereditary PD, those that carry PD...
- Parkinson’s Disease Therapeutics Pipeline Program, 2025Developing Novel Lysosome-based Translational Biomarkers and Ion-Channel Agonists as Therapeutics for Parkinson’s Disease
Study Rationale: Lysosomal dysfunction impairs cells’ ability to recycle their damaged components and is a primary contributor to the progression of Parkinson's disease (PD). TMEM175, a novel ion...
- Research Grant, 2025The BioFINDER Studies: Identifying Disease Stages and Effects of Co-morbidities in Neuronal Synuclein Disease
Study Rationale: Neuronal synuclein disease (NSD) is the underlying cause of Parkinson’s disease (PD) and similar disorders. Recently, new tests have allowed us to measure signs of NSD before symptoms...
- Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2025Validating Hallmarks of Inflammation in a Preclinical Alpha-synuclein Model of Parkinson’s Disease
Study Rationale: Inflammation and abnormal protein clumps in the brain are strongly associated with Parkinson's disease (PD). To study the mechanism of inflammation and disease progression related to...
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