The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Defining Cognitive Phenotypes of Parkinson’s Disease, 2011Bioanatomical Phenotype of Parkinson's Disease With and Without Cognitive Impairment
Objective/Rationale:
Mild cognitive impairment (MCI) and dementia are common in Parkinson’s disease. However, presently, it is difficult to recognize which aspects of cognitive changes are... -
Improving Levodopa Delivery, 2011Continuous Subcutaneous Levodopa Prodrug Infusion
Objective/Rationale:
Numerous studies demonstrate that continuous levodopa infusion can result in reductions of more than 50 percent in time spent in the "off" state and time spent with severe... -
Target Validation, 2011Caspase-8 Control Microglia Activation and Neurotoxicity in Parkinson's Disease
Objective/Rationale:
Sustained microglia activation and resulting neuroinflammation is believed to play an important role in the mechanism of chronic dopaminergic neuronal loss in Parkinson’s disease... -
MJFF Research Grant, 2011Development of Highly Sensitive and Specific Antibodies Against Oxidized DJ-1 as a Biomarker for Parkinson's Disease
Objective/Rationale:
Mutations in the DJ-1 gene are associated with an early-onset familial form of PD and DJ-1 protein has been shown to be lower in the CSF of sporadic PD compared to controls. DJ-1... -
Defining Cognitive Phenotypes of Parkinson’s Disease, 2011Neurochemical Correlates of Cognitive Phenotypes in PD
Objective/Rationale:
Parkinson’s disease causes neurodegeneration in multiple subcortical nuclei, including substantia nigra, locus coeruleus, dorsal raphe nucleus, and nucleus basalis. Each of these... -
Target Validation, 2011TGF-beta Signaling as Novel Therapeutic Treatment for Parkinson's Disease
Objective/Rationale:
Finding ways to protect dopaminergic neurons from degeneration could provide new therapies for Parkinson’s disease (PD). Transforming growth factor betas (TGF-betas) are essential...
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Our funding programs support basic, translational and clinical research from academia and industry.