The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Advancement Program, 2018Evaluation of PARIS ASOs in Models of Parkinson's Disease
Study Rationale:
The parkin-interacting substrate (PARIS) prevents genes that are important in the survival of dopamine neurons from working by limiting their expression in neurons. Previously we... -
Therapeutic Pipeline Program, 2018Bitopertin to Alleviate Dyskinesia in Parkinson's Disease
Study Rationale:
Levodopa-induced dyskinesia is abnormal involuntary movements that can affect people with Parkinson's disease after years of treatment. Available therapies for dyskinesia are only... -
Research Grant, 2018pS65-Ub as a Biomarker for Parkinson's Disease
Study Rationale:
The PINK1 and parkin proteins jointly ensure quality control of mitochondria, the cell's powerhouse. Together they modify damaged mitochondria with phosphorylated ubiquitin (pS65-Ub)... -
Research Grant, 2018Exploring the Effect of Altitude on Parkinson's Disease
Study Rationale:
There is a lot of anecdotal evidence that the symptoms of Parkinson's disease (PD) may improve markedly during visits to high-altitude destinations. Given the significant, but as yet... -
Research Grant, 2018URMC-099 in an In Vivo AAV-hSYN Model of Parkinson’s Disease
Study Rationale:
Parkinson's disease (PD) can be modeled by over-expressing human synuclein, a protein that can clump together to disrupt normal signaling in dopamine-containing neurons, which in turn... -
Research Grant, 2018LRRK2-Mediated Rab Protein Phosphorylation in Monocytes and Neutrophils in Parkinson's Disease
Study Rationale:
Mutations in the LRRK2 gene cause some forms of Parkinson's disease. Studying this gene's effects has provided insight into the physiological processes that lead to genetic and...
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Our funding programs support basic, translational and clinical research from academia and industry.