The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Improved Biomarkers and Clinical Outcome Measures, 2018Does the Brain's Ability to Compensate for the Shortage of Dopamine Affect Parkinson's Disease Progression?
Study Rationale:
Parkinson's disease (PD) is a progressive disorder, but it is unclear what causes the gradual worsening of the symptoms over the years. It is also unknown why in some cases the disease... -
Target Advancement Program, 2018Searching for Genes that Control Alpha-synuclein Levels in Parkinson's Disease
Study Rationale:
Alpha-synuclein is a sticky protein that clumps in the brains of people with Parkinson's disease (PD). The level of this protein in the brain correlates with the risk of Parkinson's... -
Mitochondrial Biomarkers Program, 2018Developing Precision Biomarkers of Parkinson's Disease
Study Rationale:
Leucine-rich repeat kinase 2 (LRRK2) is the greatest known genetic contributor to Parkinson's disease (PD). Research studies have linked mutations (changes) in the LRRK2 gene to DNA... -
Research Grant, 2018The Interplay between Genetic and Environmental Mechanisms in Parkinson’s Disease
Study Rationale:
Genes implicated in Parkinson's disease (PD), such as alpha-synuclein, DJ-1 and LRRK2, strongly influence the effect of environmental toxins, such as pesticide rotenone know to cause... -
Research Grant, 2018Discovery of Microbiome Biomarkers for Parkinson's Disease
Study Rationale:
The gut microbiome -- a community of microorganisms living in the gastrointestinal tract -- influences the development of the nervous system, affects behavior and contributes to... -
Target Advancement Program, 2018Hexosaminidase as a Therapeutic Target for Parkinson's Disease
Study Rationale:
Hexosaminidase (HEX) is a protein that is stored inside lysosomes, tiny bubbles inside the cell responsible for getting rid of its waste. A lack of HEX is associated with Sandhoff...
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Our funding programs support basic, translational and clinical research from academia and industry.