The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2016Investigation of LRRK2 as a Regulator of Dendritic Cell Function
Promising Outcomes of Original Grant:
Myeloid cells (white blood cells) of the immune system include monocytes, neutrophils and dendritic cells found in circulation, as well as microglia (immune system... -
Research Grant, 2016Chemical Knockdown of LRRK2 by Small Molecule PROTACS
Study Rationale:
LRRK2 is a protein kinase that appears to be a key driver of some forms of Parkinson's disease (PD). Several potent, selective, brain-penetrant LRRK2 kinase inhibitors have been...
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Target Advancement Program, 2016Using LRRK2 Computer Simulations to Identify Therapeutic Targets for Parkinson's Disease
Study Rationale:
LRRK2 interacts with over 60 proteins and alters several molecular pathways, including autophagy (cell break down), mitochondria (powerhouses of the cell), neurites (cellular... -
Target Advancement Program, 2016Targeting the Cell's Energy System in Parkinson's Disease
Study Rationale:
Mitochondria, cellular power plants, malfunction in Parkinson's disease (PD) and with advanced age. Aging and PD cause changes in communication between mitochondria and the rest of... -
Target Advancement Program, 2016Role of Inflammation in Parkinson's Disease
Hypothesis:
We hypothesize that the inflammatory protein galectin-3 contributes to PD progression.Study Design:
We will use pre-clinical models that lack galectin-3 to evaluate inflammation, neuronal... -
Research Grant, 2016Parkinson's Disease Research Database
Study rationale:
Advances in our understanding of the genetics of Parkinson's disease (PD) have led to the generation of an array of pre-clinical models that mimic various hallmarks of the disease...
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Our funding programs support basic, translational and clinical research from academia and industry.