The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Aligning Science Across Parkinson's, 2020The Genome-Microbiome Axis in the Cause of Parkinson Disease: Mechanistic Insights and Therapeutic Implications from Experimental Models and a Genetically Stratified Patient Population
Study Rationale:
Mutations in the gene for glucocerebrosidase (GBA) increase alpha-synuclein expression and are common in Parkinson's disease (PD). However, only about a third of people with GBA... -
Aligning Science Across Parkinson's, 2020Co-Pathologies Drive Neuroinflammation and Progression in PD
Study Rationale:
While Parkinson’s disease (PD) is considered a synucleinopathy, the clinical progression of PD is driven by additional pathological proteins such as tau and beta-amyloid. Our... -
Research Grant, 2020Discovery of Selective PET Imaging Agents for Tauopathies and Alpha-Synuclein
Study Rationale:
For reasons not yet understood, a protein called alpha-synuclein clumps in the brain cells of people with Parkinson’s disease. Some evidence suggests that a protein called tau also... -
Research Grant, 2020Detecting Colonic Alpha-synuclein with an Antibody Specific for Disease-associated Forms as a Biomarker of Parkinson’s Disease
Study Rationale:
Despite several published studies using different anti-alpha-synuclein antibodies, to date no lab-based methods have been able to reliably identify Parkinson’s disease (PD) cases from... -
Improved Biomarkers and Clinical Outcome Measures, 2020Quantification of S129 Phosphorylated Alpha-Synuclein Using the AlphaLISA Immunoassay Platform
Study Rationale:
In Parkinson's, there remains an unmet need for biomarkers to track disease progression and efficacy of potential therapies. This team of investigators is focused on fluid-based... -
Improved Biomarkers and Clinical Outcome Measures, 2020PPMI DATIQ and SR T1w MRI Analysis
Study Rationale:
Parkinson’s disease results in functional and structural changes in the brain. Non-invasive imaging methods such as SPECT and MRI can measure these changes. The dopamine transporter...
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Our funding programs support basic, translational and clinical research from academia and industry.