The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2018Studying Monocyte Entry into the Brain in Alpha-synuclein-induced Parkinson's Disease (supplement)
Study Rationale:
In the past, we demonstrated that entry of CCR2-positive monocytes into the brain is required for alpha-synuclein-induced inflammation and neurodegeneration in a model of Parkinson's... -
Research Grant, 2018Measuring Protein Modifications to Monitor the Efficacy of LRRK2 Inhibitors
Study Rationale:
Leucine-rich repeat kinase 2 (LRRK2) is the greatest known genetic contributor to Parkinson's disease (PD). One important function of LRRK2 is to modify itself and proteins called Rab... -
Target Advancement Program, 2018Interactions Between Alpha-synuclein and Glycoproteins as a Therapeutic Target
Study Rationale:
In Parkinson's disease (PD), the sticky protein alpha-synuclein clumps in the brain, causing cell death. Such toxic alpha-synuclein clumps can spread from cell to cell and multiply. It... -
Target Advancement Program, 2018Investigating Alpha-synuclein Clumping in the Organoid Model of Parkinson's Disease
Study Rationale:
Alpha-synuclein -- a sticky protein that clumps in the brains of people with Parkinson's disease (PD) -- is a major target for the development of therapies for PD. Alpha-synuclein... -
Inflammation Biomarkers Program, 2018The Role of Inflammation and Risk of Parkinson's Disease in People with GBA1 Mutations
Study Rationale:
Mutations (changes) in GBA1, the gene that directs the production of the glucocerebrosidase (GBA) protein, can increase the risk of Parkinson's disease (PD) in some people, but not in... -
Mitochondrial Biomarkers Program, 2018Searching for Signs of Mitochondrial Breakdown in People with Parkinson’s Disease with an Unknown Cause
Study Rationale:
Some inherited forms of Parkinson's disease (PD) are caused by mutations (genetic changes) that lead to the breakdown of mitochondria, cell's energy generators. In some cases of...
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Our funding programs support basic, translational and clinical research from academia and industry.