The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Advancement Program, 2016Evaluation of the Parkin Pathway to Study Neural Mitophagy
Study Rationale:
Parkin is a protein that is disrupted in early onset Parkinson's disease and is believed to function in a cell-protective pathway (called mitophagy), which eliminates faulty... -
Research Grant, 2016Investigative Safety Study in LRRK2 Pre-clinical Models
Objective/Rationale:
Alternations in kidney function have been observed in pre-clinical models of LRRK2 that may represent potential safety liabilities of LRRK2 kinase inhibitor therapeutics for the... -
Research Grant, 2016Modelling LRRK2 Structure and Characterizing the LRRK2 Activation Cycle in LRRK2-mediated Parkinson's disease
Promising Outcomes of Original Grant:
We modelled the three-dimensional structure of full-length leucine rich repeat kinase 2 (LRRK2) using a mixed approach, combining protein models with experimental... -
Research Grant, 2016Analysis of Parkin Activity in Pre-clinical Models of Parkinson's
Study Rationale:
Loss-of-function mutations in parkin cause approximately 50% of cases of early-onset Parkinson's disease (PD). Parkin selectively targets impaired mitochondria (powerhouses of the... -
Target Advancement Program, 2016Targeting the LRRK2-PAK6 Pathway in Parkinson's Disease
Study Rationale:
LRRK2 is one of the most attractive therapeutic targets in Parkinson's disease (PD); however, chronic doses of LRRK2 inhibitors result in side effects in pre-clinical models. We... -
Improved Biomarkers and Clinical Outcome Measures, 2016Study of Drug Binding Sites in Alpha-synuclein Fibrils
Objective/Rationale:
This research aims to improve the potential to treat Parkinson's disease (PD) by using active molecules. Various small molecules that produce desired effects have been shown to...
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Our funding programs support basic, translational and clinical research from academia and industry.