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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2014
    Rating Segmental Progression of Cardinal Motor Symptoms in Early Parkinson's Disease

    Objective/Rationale: 
    We recently reported a new, practical approach to rate segmental progression of cardinal motor symptoms in Parkinson's disease (PD) at early stages. We computed four new scores —...

  • Access to Data and Biospecimens, 2014
    Contribution of the Unfolded Protein Response to Idiopathic and LRRK2-driven Parkinson’s Disease

    Objective/Rationale:             
    The unfolded protein response (UPR) is a life-death switch that instructs aged and overworked cells to self-destruct. We hypothesize that hyper-activation of the UPR...

  • Research Grant, 2014
    Role of LRRK2 in Alpha-synuclein-induced Neurodegeneration: Supplement

    Promising Outcomes of Original Grant:
    We seek to develop a robust and standardized pre-clinical model relevant to late-onset Parkinson’s disease (PD) that will identify clinically viable LRRK2 kinase...

  • Rapid Response Innovation Awards, 2014
    Integrative Genomic Approach to Discover Disease Mechanisms Underlying Parkinson’s Disease

    Objective/Rationale:             
    Complex diseases such as Parkinson’s are caused by a combination of genetic, environmental and lifestyle factors that all lead to different causal regulation...

  • Research Grant, 2014
    Tumorigenesis in Parkinson’s Disease

    Objective/Rationale:             
    The aim of the study is to investigate whether disease-causing genetic mutations in Parkinson’s disease (PD), particularly in the LRRK2 gene, also predispose...

  • Target Validation, 2014
    Targeted Disruption of TRIM28 to Reduce Alpha-synuclein Levels

    Objective/Rationale:
    We have previously performed a screen to find new pathways that may regulate alpha-synuclein, the toxic protein that accumulates in the cells of people with Parkinson’s disease (PD...

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