The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2012Development of an HTS Assay to Break the Alpha-Synuclein-Glucocerebrosidase Feedback Loop
Objective/Rationale:
We aim to develop a novel screening platform to identify candidate drugs to treat Parkinson’s disease. The screening platform incorporates the link between alpha... -
LRRK2 in the Immune System, 2012Does Peripheral Immune Challenge Exacerbate LRRK2-Induced Neuronal Pathology?
Objective/Rationale:
Neuro-immune interactions may have etiological roles in the development of several neurodegenerative disorders. LRRK2 is a cell signaling protein and when mutated, is... -
LRRK2 in the Immune System, 2012Clinical Evaluation of LRRK2 Inhibitors on Inflammatory Responses in Crohn's and Parkinson's Diseases
Objective/Rationale:
Leucine-rich repeat kinase 2 (LRRK2) is genetically associated with several human diseases, including Parkinson’s disease (PD) and Crohn’s disease (CD). Recent... -
Dyskinesia Challenge, 2012Combined Therapy with Amantadine and Fenobam for Levodopa-induced Dyskinesia
Objective/Rationale:
Amantadine is currently the only available medication to treat levodopa-induced dyskinesia: involuntary, jerky movements caused by long-term use of the Parkinson’s drug levodopa... -
Target Validation, 2012Cannabinoid CB2 Receptors as a New Target for the Treatment of Disease Progression in Parkinson's Disease: Studies in LRRK2-Transgenic Pre-clinical Models
Objective/Rationale:
Cannabinoids provide neuroprotection in neurodegenerative disorders through the activation of specific targets within the so-called endocannabinoid system. The case... -
Resource: Utilizing DATATOP Biospecimens, 2012Circulating MicroRNAs: a New Paradigm for Parkinson's Disease Biomarker Discovery
Objective/Rationale:
We aim to assess miRNA stability and evaluate the potential of previously identified PD-predictive circulating miRNAs as progression biomarkers for PD using MJFF...
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Our funding programs support basic, translational and clinical research from academia and industry.