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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2009
    The Role of Casein Kinase 2 in the Modulation of Dopamine Signaling in Parkinson's Disease

    Objective/Rationale:
    Parkinson’s disease is caused by a selective loss of cells in the brain that produce the neurotransmitter dopamine. The major treatment for PD is Levodopa (L-Dopa) which gets...

  • Research Grant, 2022
    Development And Validation Of A Miro1 Biomarker Assay Using White Blood Cells

    Study Rationale: The mitochondrial protein Miro1 fails to be degraded and this defect impairs mitophagy in more than 90% of all Parkinson’s disease (PD) patients of both genetic and sporadic forms...

  • Aligning Science Across Parkinson's, 2021
    Understanding and Manipulating Cellular and Circuit-level Vulnerability to Neurodegeneration in Parkinson’s Disease
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    Study Rationale:
    Many people with Parkinson’s disease develop untreatable cognitive symptoms, including problems with attention, decision-making, and dementia at late stages of the disease, due to...

  • Therapeutic Pipeline Program, 2013
    Pre-clinical Evaluation of Neuroprotective Small Molecule Erythropoietin Receptor Agonists in the Treatment of Parkinson’s Disease

    Objective/Rationale:             
    Erythropoietin (EPO) receptor is present throughout the body and plays a role in both red blood cell production and tissue protection.  STATegics has discovered small...

  • Therapeutic Pipeline Program, 2013
    Exenatide as a Treatment for Patients with Parkinson’s Disease

    Objective/Rationale:             
    Laboratory data from several teams have indicated potential beneficial effects of the drug Exenatide on the survival of dopamine cells. In a small group of patients...

  • Dyskinesia Challenge, 2012
    The Effects of Memantine on Levodopa Induced Dyskinesias (LIDs) in MPTP-treated Pre-clinical Models

    Objective/Rationale:
    Levodopa is the mainstay of treatment for the motor symptoms of Parkinson’s disease.  Unfortunately one of the long term side effects of levodopa treatment is the development of...

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