The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2010Characterization of PARK16
Objective/Rationale:
Recently, a novel region of the genome containing genetic information predisposing to the development of Parkinson’s disease has been discovered through a collaborative study of... -
Rapid Response Innovation Awards, 2010Deciphering the Molecular Effects of Alpha-Synuclein in the Nucleus: DNA Binding and Transcriptional Dysregulation
Objective/Rationale:
A-synuclein, the main component of Lewy bodies, is thought to be present mostly on nerve terminals. Although the function of a-synuclein is unclear, its presence in the nucleus of... -
Rapid Response Innovation Awards, 2010Susceptibility Genes for Antipsychotic-induced Extrapyramidal Symptoms as Modifier Genes in Parkinson's Disease and L-dopa Treatment Response
Objective/Rationale:
The use of antipsychotic drugs, all of which block dopamine D2 receptors, to treat schizophrenia and other psychotic states is associated with the development of motor acute... -
Rapid Response Innovation Awards, 2010The Role of LRRK2 in Wnt Signaling In Vivo
Objective/Rationale:
We have preliminary evidence that LRRK2, which is a key protein in Parkinson’s disease (PD), may have a role in an important cellular process called Wnt signaling. Thus it is... -
Therapeutics Development Initiative, 2010Development of an Adult Adherent Allogeneic Stem Cell Product for Treatment of Parkinson's Disease
Objective/Rationale:
Previously published data illustrates that MultiStem®, an adult stem cell product approved by the FDA for Phase I studies in humans, works through multiple mechanisms of benefit... -
Rapid Response Innovation Awards, 2010Determine the Structure of Roco Family Proteins
Objective/Rationale:
Our aim is the biochemical and structural characterization of the Roco family of proteins. Structures of different Roco constructs will give important insights in the molecular...
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Our funding programs support basic, translational and clinical research from academia and industry.