The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2010Susceptibility Genes for Antipsychotic-induced Extrapyramidal Symptoms as Modifier Genes in Parkinson's Disease and L-dopa Treatment Response
Objective/Rationale:
The use of antipsychotic drugs, all of which block dopamine D2 receptors, to treat schizophrenia and other psychotic states is associated with the development of motor acute... -
Rapid Response Innovation Awards, 2010The Role of LRRK2 in Wnt Signaling In Vivo
Objective/Rationale:
We have preliminary evidence that LRRK2, which is a key protein in Parkinson’s disease (PD), may have a role in an important cellular process called Wnt signaling. Thus it is... -
Therapeutics Development Initiative, 2010Development of an Adult Adherent Allogeneic Stem Cell Product for Treatment of Parkinson's Disease
Objective/Rationale:
Previously published data illustrates that MultiStem®, an adult stem cell product approved by the FDA for Phase I studies in humans, works through multiple mechanisms of benefit... -
Rapid Response Innovation Awards, 2010Determine the Structure of Roco Family Proteins
Objective/Rationale:
Our aim is the biochemical and structural characterization of the Roco family of proteins. Structures of different Roco constructs will give important insights in the molecular... -
Pharmacodynamic Biomarkers of LRRK2 Activity, 2010Exploiting Ser910/935 Phosphorylation and 14-3-3 Binding to Develop Biomarkers for LRRK2 Activity
Objective/Rationale:
There is great excitement that drugs that target an enzyme termed LRRK2 may have utility for the treatment of Parkinson’s disease. Many companies are attempting to develop LRRK2... -
Pharmacodynamic Biomarkers of LRRK2 Activity, 2010Macrophage Precursors as Biomarker for LRRK2-associated Parkinson disease
Objective/Rationale:
LRRK2 mutations significantly contribute to the development of Parkinson Disease, a multisystem disorder. Neuronal loss is a prerequisite to develop the disease and a crosstalk...
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Our funding programs support basic, translational and clinical research from academia and industry.